What are the applications of irreversible inhibition in biochemistry?

What are the applications of irreversible inhibition in biochemistry?

Irreversible inhibition is used in drug design, particularly for targeting enzymes in diseases like cancer and bacterial infections.

Can you give me an example of a drug that uses irreversible inhibition?

Sure! Aspirin is a well-known example; it irreversibly inhibits the enzyme cyclooxygenase, reducing pain and inflammation.

How does irreversible inhibition differ from reversible inhibition?

Irreversible inhibition permanently binds to the enzyme, while reversible inhibition allows the enzyme to regain activity after the inhibitor is removed.

What are the potential side effects of irreversible inhibitors?

Potential side effects can include toxicity and off-target effects, as they may affect other enzymes or pathways.

Are there any recent advancements in irreversible inhibition research?

Yes, researchers are exploring new irreversible inhibitors for targeted cancer therapies and antibiotic resistance.