What are the differences between reversible and irreversible inhibitors?

What are the differences between reversible and irreversible inhibitors?

Reversible inhibitors bind to enzymes non-covalently and can be removed, while irreversible inhibitors form covalent bonds and permanently inactivate the enzyme.

Can you give examples of each type of inhibitor?

Sure! An example of a reversible inhibitor is competitive inhibitors like methotrexate, while aspirin is an example of an irreversible inhibitor.

How do these inhibitors affect enzyme activity?

Reversible inhibitors decrease enzyme activity temporarily, while irreversible inhibitors permanently reduce enzyme activity by modifying the enzyme.

Are there any clinical applications for these inhibitors?

Yes, reversible inhibitors are often used in drug design to regulate enzyme activity, while irreversible inhibitors can be used in treatments like cancer therapy.