What are the mechanisms of enzyme inhibition?
Enzyme inhibition occurs when a molecule binds to an enzyme and decreases its activity. There are several mechanisms, including competitive, non-competitive, and uncompetitive inhibition.
Can you explain competitive inhibition?
Sure! In competitive inhibition, an inhibitor competes with the substrate for binding to the active site of the enzyme. This means that increasing substrate concentration can overcome the inhibition.
What about non-competitive inhibition?
In non-competitive inhibition, the inhibitor binds to an enzyme at a site other than the active site, which changes the enzyme's shape and reduces its activity, regardless of substrate concentration.
Are there any examples of enzyme inhibitors in medicine?
Yes, many drugs act as enzyme inhibitors. For example, statins inhibit HMG-CoA reductase to lower cholesterol levels.
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